BEinCPPS project aims to integrate and experiment a Fl-based machine-factory—cloud service platform firstly intensively in five selected S3 Vanguard regions, afterwards extensively in all European regions, bv involving local competence centers and manufacturing SMEs. The final aim of this IA is to dramatically improve the adoption of CPPSs all over Europe by means of the creation, nurturing and flourishing of CPS-driven regional innovation ecosystems, made of competence centers, manufacturing enterprises and IT SMEs.